Stimulation of hematopoiesis by femoral marrow curettage in sublethally irradiated mice.

Femoral bone marrow curettage produced tion. It is suggested that the primitive an intense stimulus on hematopoietic stem mesenchymal cells synthesize a humoral cells (HSC) in sublethally irradiated mice factor that is capable of stimulating HSC 4 days after curettage. A similar but lesser in a marrow microenvironment of depleted stimulation of 59Fe incorporation into cellularity. The observations are consistent spleen and red cells was observed. Prowith a hypothesis of inhibition of HSC vious investigations have shown that this response to a similar stimulus in a normoeffect is not observed in unirradiated mice. cellular marrow by a mechanism of cell-cell Histologic studies of the curetted femurs interaction. The humoral factor affects HSC indicated a rapid regeneration of a primisimilar to fetuin, spleen extract, and alpha tive mesenchymal tissue within the medulglobulin fractions. Iary cavities during the period of stimula-